Super-resolution

  • Stimulated Emission Depletion super-resolution imaging
  • High sensitivity point scanning confocal with pulsed white light laser
  • High-sensitivity GaAsP HyD detectors with gating and photon counting
  • Spectrally tunable emission bands
  • Resonant scanner for low photo-toxicity
  • Inverted configuration
  • 3D z-stacks, timelapse, stitching, multi-position timelapse

  • Optical trapping of beads or protein or membrane complexes
  • Confocal imaging  between two optical traps with 488nm and 561nm lasers
  • DNA–binding protein experiments: Study molecular mechanisms involved in DNA organization, repair, replication, transcription, and RNA translation.
  • Others: Protein folding; Cytoskeleton structure and transport; Mechanobiology.
  • Phase separation.
  • Immuno-oncology.

The ZEISS Elyra 7 is a versatile super-resolution microscope system which combines high-speed live-cell imaging with subcellular detail, offering resolution of 100-120nm with SIM and even down to 60 nm with Lattice SIM² or 20-30 nm with SMLM - single molecule localization microscopy (like PALM/dSTORM) for molecular precision. Its key capabilities include fast 3D imaging with dual sCMOS cameras, gentle illumination for live samples, wide-field capabilities, DIC, and TIRF or HILO.

Highly inclined and laminated optical sheet (HILO) and total internal reflection illumination (TIRF).

Apotome 2: Grid-based optical sectioning to create highly contrasted images with high lateral and axial resolution.