About LMCF

The Light Microscopy Core Facility (LMCF) offers a wide range of confocal and conventional fluorescence microscopes and image analysis resources. The facility is based in the LSRC, the FFSC (French Family Science Center), the Nanaline Duke building and Research Park II at Duke University and is open to all members of the University and the Medical Center campuses.

As a centrally funded shared resource, we aim to offer affordable and efficient access to standard and advanced imaging instrumentation for users of all levels of experience and from any discipline. Dedicated staff provide training and full technical support for all the instruments.

If you are interested in using imaging techniques in your research, please see the equipment, capabilities, courses, guides and services offered by the facility and request training for any resource you wish to use. If you have any questions, please contact the facility.


Images of the equipment and rooms in LMCF are available here



The facility recovers some of the direct costs through user fees. The fees for using the microscopes are heavily subsidized by generous funding from the following sources:

Duke University office of the provost
duke university school of medicine
duke comprehensive cancer center

North Carolina Biotechnology Center

NIH Shared instrumentation grant 1S10RR027528-01 funded the DeltaVision, NIH shared instrumentation grant 1S10RR027867-01 funded the intravital confocal/multiphoton systems, NIH shared instrumentation grant 1S10-OD020010-01A1 funded the Lightsheet, IDG #2011-IDG-1002 from NCBC funded the Olympus VivaView.


The facility is heavily used by many labs from across Duke. Since begining operation LMCF has been used over 66,000 times by over 2200 users from over 480 labs across all research departments totaling over 170,000 hours of use. Many publications have resulted from the use of the microscopy facility in recent years. Images from the microscopes can be seen in the image gallery.


LMCF was initially formed from several departmental microscope resources in the LSRC. The Department of Biology and the Department of Pharmacology & Cancer Biology teamed up, along with the then Comprehensive Cancer Center's Confocal Microscopy Shared Resource, to hire a Director in 2006 to establish and run a cooperative microscope facility for the two departments.

The facility received substantial funding from the Office of the Provost and the Dean of the Medical School in 2007 to purchase new equipment and become a resource for the entire Duke community. The facility remains a Duke Cancer Institute Shared Resource. In 2011 systems previously run as a resource for the Cell Biology department where incorporated into LMCF.


The facility is overseen by a Faculty Advisory Committee, which in turn is overseen by designates of the Provost and the Dean of the Medical School.

Faculty Advisory Committee

Danny Lew, Co-Chair (Pharmacology & Cancer Biology)
Dan Kiehart, Co-Chair (Biology)
John Rawls (Molecular Genetics & Microbiology)
Emily Derbyshire (Chemistry)
Ashutosh Chilkoti (Biomedical Engineering)
Scott Soderling (Cell Biology)
Vann Bennett (Biochemistry)
David Sherwood (Biology)
Don Fox (Pharmacology & Cancer Biology
Fan Wang (Neurobiology)
Brent Hoffman (Biomedical Engineering)

About microscopy.duke.edu

The LMCF website aims to be a clear and concise source of relevant information. If you spot any mistakes or have comments or suggestions for improvements please let us know.

Updated 9-may-16 11:06